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17 Hydroxyprogesterone is a hormone made by the adrenal glands, which are present above the kidney. 17 hydroxyprogesterone acts as a building block for producing cortisol hormone. The cortisol hormone maintains blood pressure, the immune system, and blood sugar. In certain conditions, the 17 hydroxyprogesterone (OHP) may be produced at a low or higher level. This leads to impaired formation of the cortisol hormone, which affects certain body functions. 17-Hydroxyprogesterone Stimulation by Acth Test measures the level of 17 hydroxyprogesterone(OHP) in the blood.
A doctor may recommend this Test
In case he suspects congenital adrenal hyperplasia(CAH). CAH is a genetic disorder that prevents the adrenal gland from making enough cortisol. As the adrenal glands work harder to make more cortisol, they produce extra 17-OHP and certain male sex hormones.
17 OHP is done on infants born with outer genitals that do not look like those of a boy or a girl.
In patients undergoing treatment for 17 OHP
In females with hirsutism
In females with polycystic ovarian disease
17 OHP is a blood test done as a part of testing for CAH and is now, by law, part of newborn screening. A newborn screening is a simple blood test that checks for various serious diseases.
Newborn Babies (more than 24 hours old): less than 400 to 600 nanograms per deciliter (ng/dL).
Children before puberty around:100 ng/dL or 3.03 nmol/L.
Adults: less than 200 ng/dL or 6.06 nmol/L
Cord blood: 1000-3000 ng/dL
This test is done in indeterminate cases of 17OHP elevations (marginally elevated cases between 200-1000 ng/dL in adults)
Blood is collected from the vein for baseline 17OHP levels, Zero hour/Baseline sample
A predetermined dose of synthetic ACTH injection is given at 0 min and blood samples collected at 30, 60 min for 17-OHP estimation.
ACTH stimulates production of 17-OHP.
A positive report means that there is a possibility of CAH and the patient requires further investigations in the form of genetic testing
A female patient with polycystic ovarian disease with raised 17 OHP requires further investigation.