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17 - Hydroxy-Progesterone, Newborn Screening Test

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10006

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Monday / Wednesday / Friday

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1 drop of heel prick Blood each on 5 spots of filter paper available from Aster Labs (AL-GF-0013.)Clinical details and drug history must accompany sample

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24 Hours

Price

₹250

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Parameters
17-OHP

 What is 17 hydroxyprogesterone (newborn screening test)?

The adrenal cortex primarily produces cortisol. The hormone cortisol is made from the hormone 17-hydroxyprogesterone as a precursor. To measure the level of 17-hydroxyprogesterone (17-OHP) in newborns, heel prick capillary blood samples are spotted onto filter paper. The test measures the 17-OHP level and looks for congenital adrenal hyperplasia. Congenital adrenal hyperplasia is a genetic disorder that prevents the adrenal gland from making enough cortisol. 

When does the doctor recommend 17 hydroxyprogesterone (newborn screening test)?

The doctor may recommend this test 

  • To diagnose a rare genetic disorder called congenital adrenal hyperplasia 

  • The test is done as part of a group of routine screening tests or on all newborns to allow early detection and treatment of certain diseases.

  • In newborns whose outer genitals do not look like those of a girl or a boy.

  • In children showing abnormal development of sex organs and sexual characteristics.

  • In patients already undergoing treatment for CAH. 

What are the components of the 17 hydroxyprogesterone test?

The baby's heel is cleaned with alcohol and pricked with a small needle for newborn screening. Then the blood is collected, and the sample is sent for test. The test is usually performed within  1 or 2 days of birth. The symptoms vary depending on the severity of the disease.

What is the normal range of the 17 hydroxyprogesterone test?

Babies more than 24 hours old - less than 400 to 600 nanograms per deciliter (ng/dL)

Children before puberty - 100 ng/dL or 3.03 nmol/L

  • High levels indicate CAH (Very high levels indicate the severe form)

  • Moderately high levels indicate the milder/intermediate form of the condition.

  • Lower levels indicate the treatment is working.

Note: CAH is a genetic disorder, so consulting a genetic counsellor may be beneficial before the treatment.

What are the prerequisites for the test?

No special preparations are required.



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